The rs2116519 (C→T) SNP of the family with sequence similarity 78, member B gene (FAM78B, recessive model), rs6929846 (T→C) of the butyrophilin, subfamily 2, member A1 gene (BTN2A1, dominant model), rs146021107 (G→-) of the pancreatic and duodenal homeobox 1 gene (PDX1, dominant model) and rs1671021 (G→A) of the lethal giant larvae homolog 2 gene (LLGL2, dominant model) were significantly (P<0.05) associated with the prevalence of hypertension. The gene discussed is FAM78B; the disease is Hypertension.