PDCD4 and familial pancreatic carcinoma: For instance, miR-150 and miR-630 induce pancreatic cancer cell apoptosis by targeting insulin-like growth factor 1 (IGF-1R), while miR-21 functions as an anti-apoptotic regulator by targeting pro-apoptotic genes, such as Fas ligand (FasL), phosphatase and tensin homolog (PTEN) and programmed cell death protein 4 (PDCD4) (15).