In breast cancer cells, nordihydroguaiaretic acid inhibits mTORC1 activity through disruption of mTOR-Raptor complex and AMPK activation [128], while demethoxycurcumin, a potent AMPK activator has broad spectrum anticancer activity in triple-negative breast cancer cells [129] with the parent compound curcumin exerting similar effects in ovarian cancer cells [130] and in colorectal cancer cells by AMPK-p53 activation [131, 132]. This evidence concerns the gene PRKAA1 and colorectal cancer.