TCIRG1 and rickets: Radiographs also revealed metaphyseal fraying and cupping (Fig. 1I), indicative of rickets superimposed on osteopetrosis, or “osteopetrorickets.” To confirm this, we compared Snx10 KD mice with Tcirg1 (Atp6i) KO mice [23], which display both hypocalcemia and osteopetrorickets [11].