Finally, infection of Snx10 KD splenocytes with a retrovirus expressing Snx10 reintroduced Snx10 expression (S2D Fig., bottom panel) and corrected the pit formation defect (2.25 +/− 0.62 mm2 n = 6, p = 0.008), confirming that Snx10 deficiency is responsible for the resorption defect (S2D Fig., top and middle panels). The gene discussed is SNX10; the disease is infection.