All-trans retinoic acid, another first-line drug for leukemia, suppressed the mammosphere-forming ability which was correlated with the reduced expression of SOX2 and elevated expression of its antagonist CDX2 in breast CS-like cells [35].  The FDA approved flubendazole is extensively used as an efficacious anthelmintic drug in gastrointestinal parasites disease [21-23]. Here, SOX2 is linked to leukemia.