First, low calcemic analogs of Vitamin D are potent inhibitors of rodent melanoma cells proliferation; Second, mildly pigmented melanoma cells are more sensitive to several Vitamin D analogs than non-pigmented ones; Third, pigmented cells not only show attenuation of ligand-induced translocation of VDR to the nucleus but also ligand-induced expression of VDR and CYP24A1 genes is reduced in comparison to non-pigmented cells; Last, nuclear localization of VDR and activation of the classical (genomic) Vitamin D response pathway may not be necessary for growth inhibition of murine cells. Here, CYP24A1 is linked to melanoma.