Our results are in agreement with the data published by the group of Park, showing an increased sensitivity to radiation in different cell types when IDH1 or IDH2 is silenced.22, 23, 24, 25 However, other studies show increased cell sensitivity to cell death when mutant IDH is overexpressed, in particular in ROS-mediated cell death such as radiation-26 or BCNU-induced cell death.27 However, these cells are addicted to glutaminolysis contrary to the glioma cell lines used in our study. This evidence concerns the gene IDH2 and central nervous system cancer.