Importantly, TSP50+/MMP9+ tumors were associated with a significantly higher metastasis rate, as shown in Figure 7e, 70/88 (79%) breast tumor specimens were positive for both TSP50 and MMP9, and 40/70(57%) of TSP50+/MMP9+ tumors showed one or more metastatic lymph nodes, whereas other tumors showed very fewer metastatic lymph nodes. The gene discussed is PRSS50; the disease is breast neoplasm.