STAT3 and breast cancer: The association between breast cancer and Stat3 pathway was established about 20 years ago.39 Recent studies have also reported that activated Stat3 and its overexpression were closely associated with the development of breast cancer.40 Importantly, with Stat3 being activated in ~70% of breast tumors, particularly in the less treatable triple-negative tumors, suggesting that targeting Stat3 might be a potentially important new form of breast cancer therapy.14