ACP1 and carcinoma: In these patients, a significant increase in LMWPTP expression from normal to adenoma, and adenoma to carcinoma tissue was observed (37 ± 6%, 67 ± 7% and 97 ± 1%, respectively, P < 0.001, Figure 2F), suggesting a role for LMWPTP in the oncogenic transformation of colonic epithelial cells.