Fitting with the urate-association results (S11 Table), core fucosylation (driven by FUT8) was noted to decrease with BMI [52] and transcript levels for the sialyltransferase gene ST6GALT2 to be highly stimulated by the pro-inflammatory cytokines IL6 and IL8 [53] that are potentially elevated in the systemic low-grade inflammation that characterises obesity [54]. This evidence concerns the gene CXCL8 and obesity due to melanocortin 4 receptor deficiency.