CALR and helminthiasis: For example, Schistosoma mansoni CRT is a strong T-cell immunogen capable of inducing IL-4 synthesis [11], while native Heligmosomoides polygyrus CRT has been shown to induce production of IL-4 and IL-10 by T cells from infected mice [12], suggesting that CRT is able to induce a Th2 response during helminth infections.