The analysis showed that isolates and haplotypes with C-P43T (p-value = 0.01), NS1-S103T (p-value = 0.01), NS2A-V83I (p-value = <0.001), NS3-R337K (p-value = 0.01) and NS2A-S119N (p-value = 0.02) substitutions showed significantly low odds of developing severe dengue regardless of either primary or secondary infection status (Table 3). Here, KRAS is linked to dengue disease.