Similarly, Jakobs and colleagues (2005) [41] reported loss of m+RGCs in adult mice with congenic glaucoma and in a line of mice created by crossing DBA/2J mice (which develop a pigmentary glaucoma) with Thy1-CFP mice [38], the progressive increase of the IOP was accompanied by a concomitant reduction in the numbers of RGCs and of m+RGCs, suggesting that OHT-induced progressive loss of RGCs, and of m+RGCs, could have a substantial impact on animal behavioural response patterns (Zhang et al., 2013). The gene discussed is THY1; the disease is glaucoma.