If the level of Mcl-1 is not the determining factor in the differential response of LNCaP and PC3 cells to ABT-263 treatment, one recent study may have demonstrated a different mechanism where ABT-737 induced protective autophagy to escape apoptosis in hepatocellular carcinoma with overexpression of Bcl2 [31]. This evidence concerns the gene BCL2 and hepatocellular carcinoma.