CXCL10 and neuromyelitis optica: Up-regulation of IP-10 after incubation with the sera from three subtypes of acute NMOSD patients, including definite NMO, LETM and ON groups, was also observed with high reproducibility using another specified ELISA assay, and the sera from the definite NMOSD patients caused more severe BBB damage via IP-10 production compared to that induced by the sera from the ON patients.