In addition, our data showed HIF-1α, SHH and GLI1 expression levels were related to International Neuroblastoma Staging System (INSS) stages (Fig. 1) (Spearman rho = 0.415, P < 0.0001; Spearman rho = 0.487, P < 0.0001; Spearman rho = 0.347, P = 0.003). This evidence concerns the gene GLI1 and neuroblastoma.