Results were essentially the same after adjustments for smoking habits, BMI, waist circumference, diabetes duration, HbA1c, insulin treatment, hypertension and lipid-lowering therapy in both samples as well as in the combined analysis: β (SE) for one SD of resistin increment = -1.07 (0.70), p = 0.02; -5.50 (0.88), p < 0.001; and -2.81 (0.55) ml/min/1.73m2, p < 0.001, respectively (Table 2). This evidence concerns the gene INS and diabetes mellitus.