Inflammatory cytokines in RA joints activate numerous transcription factors including nuclear factor-kappa-B (NF-κB), activator protein-1 (AP-1), janus kinase-signal transducer and activator of transcription (JAK-STAT) and the CCAAT/enhancer-binding protein (C/EBP) family. This evidence concerns the gene CEBPA and rheumatoid arthritis.