The key findings in this study have revealed that the genetic polymorphisms of LIG4 (rs1805388) and HSPB1 (rs2868371) were not evidently associated with the RILI in lung cancer patients, implying that the genetic polymorphisms of LIG4 and HSPB1 may not induce or inhibit the radiation-induced normal tissue injury in the lung cancer patients after the treatment of radiotherapy. Here, HSPB1 is linked to lung carcinoma.