This is of particular interest since it has been recently reported in a rat asthma model that local delivery of recombinant CD200 strongly reduces OVA-induced lung accumulation of myeloid DCs in the lung [16]. CD22 also known as Siglec2 is upregulated 4-fold in CD8− DCs and belongs to the family of sialic-acid-binding lectins. Here, CD22 is linked to asthma.