4G/4G genotype is associated with a higher risk of thrombosis [18, 19]; GPIIIA PlA2 polymorphism has been associated with thrombosis [20, 21]; MTHFR 677T variant allele is associated with cancer risk, influencing the clinical phenotype and the interaction with other environmental factors [22, 23]. The gene discussed is ITGB3; the disease is deep vein thrombosis.