TARDBP and Parkinson disease: These include protein aggregates of α-synuclein, a defining feature of Parkinson’s disease (PD) and dementia with Lewy bodies (DLB), as well as transactive response DNA-binding protein 43 kDa (TDP-43) that forms aggregates in subtypes of frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS), the latter also known as motor neuron disease [7,8].