However, Syrjänen et al., 2009 [26] found that IL-10 up-regulation in baseline biopsies was most consistently associated with high-grade CIN, but the expression profile of this cytokine was unrelated to HR-HPV genotypes or viral load, and was not a predictor of viral outcome and disease progression in a longitudinal setting. Here, IL10 is linked to cervical squamous intraepithelial neoplasia.