Many researches have shown that BMSCs can migrate to injured tissues via the SDF-1α/CXCR4 axis and relieve myocardial infraction [13, 14], promote wound healing [19], heal bone fracture [34], reduce cerebral ischemia [35], and ameliorate acute necrotizing pancreatitis [11]. Here, CXCR4 is linked to brain ischemia.