We cannot elucidate whether the combination of dabrafenib and ECT had an additive effect, or whether ECT, thanks to its sustained local cytotoxic activity, may enhance tumor antigen presentation and promote lymphocyte tumor infiltration, as previously reported.16,17 Moreover, the immunological benefits could have been enhanced through the silencing of the aberrant immune-depressant pathways driven by the BRAF constitutive activation.18,19. This evidence concerns the gene BRAF and neoplasm.