The fast growing rate, the size of the thyroid nodule (39 mm) and the presence of necrotic lesions and capsule invasion detected by histopathology on one side and not having the opportunity to evaluate the expression for Ret/PTC or CK-19 gene rearrangements and proliferation index Ki-67 on the other side, guided us to post-therapeutic procedure with 100 mCi 131I for achieving optimal conditions for further evaluation and disease treatment. Here, MKI67 is linked to thyroid nodule.