EGFR and neoplasm: However, at the moment of surgery, we noticed a significantly increase of these proteins probably induced by the operative stress.39,40 Furthermore, vascular normalization and normalized tumor oxygenation was observed in xeno-graft models treated by EGFR-TKIs.15,16 These data were not confirmed by the present in vivo study which failed to demonstrate a significant change in vascularization parameters recorded by DCE except for the ve which could be explained by the cetuximab-induced cytoreduction, as shown by the decreased tumour cellularity and metabolic imaging.