Both the sporadic and NF1-related tumors presented a highly altered genome with several copy number alterations, ranging from 215 in MPNST-NF1-001 to 401 in MPNST-NF1-002, affecting the majority of the genome (from 71% in MPNST-NF1-001 to 84.9% in MPNST-SP-002). This evidence concerns the gene NF1 and malignant peripheral nerve sheath tumor.