In a rat model of post-ischemic HF, a low-T3S correlated with PGC-1α and mtTFA downregulation, which corresponded to decreased mitochondrial function in the border zone; T3 replacement rescued myocardial contractility and hemodynamic parameters, while maintaining the expression of PGC-1α and mtTFA and mitochondrial function [99]. Here, PPARGC1A is linked to hydrops fetalis.