WHtR has been suggested to be equal or superior to BMI as a marker for cardiometabolic morbidity later in life in children between 4 and 18 years, because children within the same BMI category but with larger waist circumference had higher risk of having metabolic syndrome, high diastolic blood pressure, and elevated insulin level (Maffeis et al. 2008; Mokha et al. 2010). This evidence concerns the gene INS and metabolic syndrome.