JAK2 and chronic myelogenous leukemia, BCR-ABL1 positive: The Bcr-Abl oncoprotein is the driver mutation for chronic myelogenous leukemia (CML), and the Jak2(V617F) point mutation is strongly associated with acute myeloid leukemias (AML) and myeloproliferative diseases (MPD’s) [33,34,35].