Nevertheless, we note that the products of AGMO catalysis are converted to fatty acids by fatty aldehyde dehydrogenase (FALDH), and that FALDH deficiency in humans results in a combination of skin permeability barrier defects, ichthyosis, and neurological disease known as Sjögren-Larsson syndrome (Rizzo 2011). Here, ALDH3A2 is linked to ichthyosis.