However, analysis of the largest tumors from mice with either a single (5x 1mg, over one week) or continuous (5x 1mg + 1mg weekly thereafter) tamoxifen treatments showed no significant difference in final tumor mass (Fig. 3D), or mT/mG Cre-reporter activation at endpoint (Fig. 3E), suggesting that outgrowth of cells with intact FN floxed sites does not explain the maintenance of tumor growth. This evidence concerns the gene FN1 and neoplasm.