Different to V-val, del-LMP1 and China 1, previous studies showed that the f variant was observed in most of the endemic NPC cases (85.7%, 24/28 and 67.3%, 33/49 respectively in two separate studies) [7, 8] but fewer in healthy donors (7.7%, 1/13 and 17.6%, 3/17 respectively in two separate studies) [7, 54] and non-NPC tumor cases (1/19 T cell lymphoma and 9/53 EBVaGC) from endemic area [41, 54, 59]. This evidence concerns the gene PDLIM7 and neoplasm.