Wholemount staining of non-tumor-bearing glands from endpoint MMTV-Neu mice revealed that 13 of 22 Neu Timp3+/+ glands were hyperplastic, while only 5 of 37 Neu Timp3−⁄− glands showed evidence of transformation (Fig 2g), further supporting this concept. This evidence concerns the gene ERBB2 and neoplasm.