We previously reported that in primary cultured hippocampal neurons, PACAP regulates an interaction between disrupted-in-schizophrenia 1 (DISC1), a strong candidate gene for schizophrenia, and the central nervous system-specific DISC1-binding zinc finger protein (DBZ) that is involved in neurite extension [59]. This evidence concerns the gene ADCYAP1 and schizophrenia.