Interestingly, hypoglycemia significantly increased the cellular pool and cytosolic localization of Siah2 with progression of time (3-24h, P < 0.05 at 12h; Fig 2B) that correlates with up-regulation of Siah2 transcripts (~2.5 fold increase over control, P < 0.01; Fig 2C). Here, SIAH2 is linked to Hypoglycemia.