The role of NO in cardioprotection and as a therapeutic modality in myocardial repair and remodeling, has been extensively reviewed by other investigators with both eNOS and nNOS playing a significant role in lessening injury, reducing apoptosis, decreasing myocardial fibrosis and ameliorating injury mediated by both reactive oxygen (ROS) and nitrogen oxide species (RNS) [34, 35]. The gene discussed is NOS1; the disease is Myocardial fibrosis.