Studies using models of experimental autoimmune diseases such as arthritis, diabetes, and experimental autoimmune encephalomyelitis (EAE) have indicated that activation of iNKT cells by OCH ameliorates or prevents these Th1-mediated diseases, attributed to induction of IL-4 and Th2 skewing [9,10,11,12]. This evidence concerns the gene IL4 and experimental autoimmune encephalomyelitis.