CCND1 and malignant colon neoplasm: Secreted frizzled-related proteins (SFRPs), the Wnt antagonists, as a family of new colorectal tumor suppressor candidate genes, could inhibit Wnt signaling and the expression of β-catenin target genes cyclin D1 and c-myc in β-catenin-activated colon cancer SW480 and HCT-116 cells, which lead to inhibiting the tumor growth[41, 42].