ZBTB16 and posterior cortical atrophy: In addition, compared to the loss of PTEN in 10–70% of PCa [16–23], the sensitivity of PLZF loss for metastatic PCa was 84% in our study, while the specificity of PLZF loss in predicting no metastasis from low grade (Gleason 3) was 70/70 (100%) or at a minimum, 67/70 (94%) when taking into account minor focal loss.