ZBTB16 and posterior cortical atrophy: The results showed that the expression of PLZF in the prostate varied in different grades with moderate to highest expression in low grade (G3) PCa and decreased or lost expression in focus/foci of high grade (G4/5) PCa (Fig. 1K) The focus/foci of primary PCa with decreased or lost expression of PLZF corresponded to the paired metastatic PCa in the lymph node by sharing similar PLZF loss/decrease as well as similar morphologic patterns (Fig. 1L).