Promyelocytic leukemia zinc finger protein (PLZF), also known as Zbtb16 or Zfp145, first identified in a patient with acute promyelocytic leukemia, is a zinc finger transcription factor belonging to the POZ-Krüppel (POK) family that binds to specific DNA sequences with its carboxy-terminal zinc fingers and suppresses transcription by recruiting co-repressors with its aminoterminal POZ domain [6,7]. This evidence concerns the gene ZBTB16 and acute promyelocytic leukemia.