To further elucidate whether or not the decrease or loss of PLZF expression in primary PCa correlated to that of the metastatic PCa, we studied the immunohistochemical expression pattern of PLZF in both primary PCa in the prostate and the paired metastatic PCa in dissected pelvic lymph nodes of the same patient. Here, ZBTB16 is linked to posterior cortical atrophy.