Former reports had suggested a vasodilatory capacity of amylin but these studies were carried out with concentrations of amylin largely above those achievable in plasma, even in insulin resistance, an effect related to its agonistic activity on calcitonin gene-related peptide (CGRP) at such elevated concentrations [41,42], that does not seem to be mediated by NO or the endothelium [43]. This evidence concerns the gene IAPP and Insulin resistance.