The associations of age, sex, body mass index, hypertension, hyperlipidemia, diabetes, active smoking, platelet count, WBC, IL-6, hsCRP, serum creatinine and ADMA with P-selectin expression, GPIIb/IIIa activation and MPA formation were estimated in a multivariate linear regression model. The gene discussed is SELP; the disease is hyperlipidemia.