The COLEC11 homozygous genotype of the minor allele rs7567833-AA was observed significantly less often in the SEP group than in the SELN group (OR = 0.2, 95%CI = 0.08–0.90,Pcorr = 0.01), showing an association with decreased risk of urinary schistosomiasis. This evidence concerns the gene COLEC11 and urinary schistosomiasis.