Then, we further examined mTOR mitochondrial location and cellular bioenergetics in paired normal and cancer cells, including normal human breast epithelial cells MCF-10A and breast cancer MCF-7 cells; and human prostate epithelial cells 267B1 and their K-Ras transfected derivative, 267B1/Ki (Figs. 2A and 2B). The gene discussed is KRAS; the disease is breast cancer.