DBP and infection: In VGCV-treated cells, DBP was mostly confined to the original distinct replication centers associated with the input virus (this is an early DBP localization pattern; one infecting virion is thought to give rise to a single replication center) or showed uniform diffuse nuclear staining (a pattern seen in very early infection) (Figure 6A) [27,28], indicating that VGCV prevents the progression of the viral infection into the late phase.