FOXOs participate in the TGF-β response [11,13], and we show that PAX3-FOXO1 interferes with the FOXO-dependent TGF-β response: p15INK4B-inducibility by TGF-β, known to be dependent on FOXO activity [12], is restored when PAX3-FOXO1 expression is inhibited in ARMS cells. This evidence concerns the gene TGFB1 and alveolar rhabdomyosarcoma.