The significant increase in expression levels of sst2 (the main sst-receptor involved in the inhibitory actions of SST/CORT at many tissues) in MFPs of HF-fed CORT-KO and SST-KO mice could, in part, help to explain the blockade in the obesity-induced up-regulation of GH/IGF-I system observed in these two models as compared with their respective controls (WT-mice). Here, IGF1 is linked to obesity due to melanocortin 4 receptor deficiency.