IGF1 and obesity due to melanocortin 4 receptor deficiency: To analyze the effect of diet-induced obesity and the implication of SST and CORT in the regulation of GH/IGF-I, SST/CORT and ghrelin systems expression in the MFPs, we used CORT- and SST-KO female mice and their respective control fed a LF or HF diet (Fig 4).