To determine and compare the dynamics of Caspase-1 and Caspase-3 in the plasma within the first 2 years after HIV-1 infection, we measured and compared plasma caspase-1 and Caspase-3 levels in two distinct patient groups and found that caspase-1 and Caspase-3 dynamics are different between the two groups. Here, CASP3 is linked to HIV-1 infection.